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Online Journal of Veterinary Research©
Volume 24(12): 693-698, 2020.
Urine kinetics and nephrotoxic study of gatifloxacin in mastitic (S Aureus) goats.
Vishakha Singh1, Mahendra Ram2 and Birendra Kumar Roy3*
1,2,MVSc.,Teaching Associate(s), Dept. of Pharmacology & Toxicology, College of Veterinary Science & A.H., Birsa Agricultural University,Ranchi-834006, Jharkhand ,India. *Corresponding Author
Singh V, Ram M, Roy BK., Urine kinetics and nephrotoxicity of gatifloxacin in mastitic (S Aureus) goats, Onl J Vet Res., 24(12): 693-698, 2020. We report pharmacokinetics of single intravenous injection of 10mg/kg gatifloxacin in 6 healthy and mastitic Black Bengal lactating goats. Mastitis was induced by coagulase positive S. aureus. To determine nephrotoxicity we gave same dose to 6 mastitic and healthy goats once daily for 3 days and determined hematology, BUN and creatinine. Urinary pharmacokinetic parameters are shown in Table 1 below. Urine levels of gatifloxacin at 1, 3, 4, 6 and 24h were ~20% higher (P < 0.01) in goats with mastitis. Mean half life (t1/2β) and residence time was ~50% but clearance was ~34% less (p<0.01). We found no differences in hematology between any group except for white cell counts which increased ~42% and neutrophils 26%, but lymphocytes declined 26%. There was no difference in blood urea or creatinine between groups. We find that gatifloxacin is retained in urine longer in mastitic goats and does not induce nephrotoxicity.
Key words: Urine kinetics; Gatifloxacin; Goats; Mastitis; I.V.; Nephrotoxicity.