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OJVRTM
Online Journal of Veterinary Research©
Volume
24(12): 693-698, 2020.
Urine kinetics and nephrotoxic study of gatifloxacin
in mastitic (S
Aureus) goats.
Vishakha Singh1, Mahendra
Ram2 and Birendra Kumar Roy3*
1,2,MVSc.,Teaching
Associate(s), Dept. of Pharmacology & Toxicology, College of Veterinary
Science & A.H., Birsa Agricultural
University,Ranchi-834006, Jharkhand ,India. *Corresponding Author
ABSTRACT
Singh V, Ram M,
Roy BK., Urine kinetics and nephrotoxicity of gatifloxacin
in mastitic (S Aureus) goats, Onl
J Vet Res., 24(12): 693-698, 2020. We
report pharmacokinetics of single intravenous injection of 10mg/kg gatifloxacin in 6 healthy and mastitic
Black Bengal lactating goats. Mastitis was induced by coagulase positive S.
aureus. To determine
nephrotoxicity we gave same dose to 6 mastitic and
healthy goats once daily for 3 days and determined hematology, BUN and
creatinine. Urinary pharmacokinetic parameters are shown in Table 1 below.
Urine levels of gatifloxacin at 1, 3, 4, 6 and 24h were
~20% higher (P < 0.01) in goats with mastitis. Mean half
life (t1/2β) and residence time was ~50% but clearance was ~34%
less (p<0.01). We found no differences in hematology between any group
except for white cell counts which increased ~42% and neutrophils 26%, but
lymphocytes declined 26%. There was no difference in blood urea or creatinine
between groups. We find that gatifloxacin is retained in urine longer in mastitic goats and does not induce nephrotoxicity.
Key words: Urine kinetics; Gatifloxacin;
Goats; Mastitis; I.V.; Nephrotoxicity.
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