©2021-2033. All Rights Reserved. Online Journal of
Veterinary Research . You may not store these pages in
any form except for your own personal use. All other usage or distribution is
illegal under international copyright treaties. Permission to
use any of these pages in any other way besides the before mentioned must be
gained in writing from the publisher. This article is exclusively
copyrighted in its entirety to OJVR. This article may be copied once but may
not be, reproduced or re-transmitted without the express permission of the
editors. This journal satisfies the refereeing requirements (DEST) for the
Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this
page you must link directly to this page only here rather than put up your own
page.
OJVRTM
Online Journal of Veterinary Research©
(Including Medical and Laboratory
Research)
Established
1994
ISSN 1328-925X
26 (9): 695-705, 2022.
Effect of allicin
Alium sativum on acute
and chronic hind paw pain in male Wistar rats
Narges Eskandari Roozbahani, Javad Sajedianfard, Negar Karimaghaie,
Hamid Rajaian.
School of Veterinary
Medicine, Shiraz University, Iran
ABSTRACT
Roozbahani NE, Sajedianfard J, Karimaghaie
N, Rajaian H. Effect of allicin
Alium sativum on acute and
chronic hind paw pain in male Wistar rats, Onl
J Vet Res., (9):
695-705, 2022. Allicin in alium
sativum (Garlic) can reduce blood glucose, cholesterol, pressure, free radicals, parasites, viral, bacterial and fungal infections. We describe effect of aqueous extract of garlic on acute and
chronic pain in male Wistar rats induced by hind paw formalin
test. Groups of 6 rats each were injected 2.5% formalin in hind paw and
injected 5 and 2.5ml extract monitored every
5min to 60 min for pain scores 0 to 3. In controls, mean acute pain
score was 2.30±0.05 at interphase 1.47±0.13 and chronic 2.08±0.7. Compared with
controls, in rats given extract we detected reductions of ~10 to 30% in pain by
5 minutes and up 70-96% by 20min (P < 0.05) but after tended to rise to
control levels. We found differences (P<0.05)
between control and all test groups in acute phase as depicted on Figures 1 to 3
and Table 2. Greatest reduction in pain and nociceptive (P<0.05) tests of
~80% occurred in rats given 5ml/kg extract 10 to 15 minutes before formalin paw
test. Results suggest that A. sativum aqueous extract may reduce acute pain if given
10-15 minutes before hind paw formalin test. We found greater reductions in
pain with intraperitoneal injection of extract compared with oral route but
statistically no difference in nociceptive scores possibly due to absorption
and first pass effect.
Key words: Garlic, Pain, Analgesia, Formalin test, Rat
FULL-TEXT (SUBSCRIPTION OR PURCHASE TITLE)