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OJVRTM

Online Journal of Veterinary Research

Volume 24 (4):198-210, 2020


Effect of gallic acid on aluminum chloride induced liver toxicity and DNA fragmentation in rats.

 

Batool Sareem Zekair and Khalisa Khadhim Khudair.

 

Department of Physiology. Biochemistry. and Pharmacolology, College of Veterinary Medicine, University of Baghdad, Iraq.

 

ABSTRACT

 

Zekair BS, Khudair KK., Effect of gallic acid on aluminum chloride induced liver toxicity and DNA fragmentation in rats, Onl J Vet Res., 24 (4):198-210, 2020. We report effect of gallic acid on aluminum chloride induced hepatic toxicity and DNA fragmentation in adult Wistar rats. Groups of 6 rats each were given 100mg/kg gallic acid IP, with or without 150mg/kg oral aluminum chloride daily for 60 days. Controls were given distilled water. Fasting blood samples were collected monthly (3) for liver function tests. At euthanasia, liver tissue was excised for DNA fragmentation tests. Compared with controls (P < 0.05), in rats given aluminum chloride we found elevated serum alanine (~70-94%), aminotransferase (~44-73%), alkaline phosphatase (~22-33%) and gama-glutamyl-transferase (26-43%). Aluminum chloride induced liver DNA fragmentation detected by comet assay (30-80%). In those given gallic acid with aluminum chloride the values were 68-92%, 31-67%, 15-27%, respectively and no change with alkaline phosphatase or DNA fragmentation.

 

Key Words: Gallic acid, ALCL3, DNA fragmentation, liver enzymes.