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OJVRTM
Online Journal of Veterinary Research©
Volume
17 (12):604-612, 2013. Extensively Redacted 2017.
Clinical
and histopathological
effects of chronic Fumaria parviflora extract on Sprague–Dawley rats
Javad Tajik1, Azizolah Khodakaram Tafti2,
Mosayeb Evazzadeh3
1Department of Clinical Studies, School
of Veterinary Medicine, Shahid Bahonar
University of Kerman, 2Department of Pathobiology, 3School
of Veterinary Medicine; Shiraz University, Shiraz, Iran
ABSTRACT
Tajik J, Khodakaram Tafti
A, Evazzadeh M., Clinical and histopathological
effects of chronic gavaged Fumaria
parviflora extract in Sprague–Dawley rats. Onl J Vet Res., 17
(12):604-612, 2013. Clinical
effects of chronic use of Fumaria parviflora on hepatic, renal,
lung and cardiac tissues were evaluated in Sprague–Dawley
rats. Three groups of 10 rats each were gavaged 100, 200 or 300 mg/kg F. parviflora hydro-alcoholic extract daily for 30 days. Ten control rats
were given gavaged saline. The rodents were
euthanized at day 30 and cardiac, lung, hepatic, and renal tissue samples were
taken. None of the treated rats showed clinical signs of toxicity.
However, hepatic and renal hyperemia occurred and apparent F. parviflora dose dependent lesions were visible in
liver, kidney and lung. Microscopically, hyperemia and cell swelling of
proximal tubules in renal tissues, hyperemia, fatty change and cell swelling in
hepatic tissues and hyperemia in lung tissues
was found in all rats given F. parviflora .
The findings suggest that chronic administration of F. parviflora extract
even at low doses induces hepatic and renal lesions in rats.
Key words: Fumaria
parviflora, Long-term, Toxicity,
Histopathological, Rat.
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