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Online Journal of Veterinary Research©
Volume 23 (12):1153-1169, 2019.
Effect of phosphatidyl choline on fructose induced metabolic syndrome in adult female Wistar rats.
Manar A Surour and Khalisa K Khudair.
Dept. of Physiology, biochemistry and Pharmacology, College of Veterinary Medicine, University of Baghdad, Iraq.
Surour MA, Khudair KK, Effect of phosphatidyl choline (PC) on fructose induced metabolic syndrome in adult female Wistar rats, Onl J Vet Res., 23 (12):1153-1169, 2019. Three groups of 7 rats each were gavaged daily for 62 days 1g/kg phosphatidylcholine (PC) (Group 1) with (2) or without 40% fructose (3) Controls were gavaged water (4). At day 62, rats were fasted 8-12 hrs and cardiac blood taken for serum glutathione (GSH), malondialdehyde (MDA), glycemic index glucose, insulin and insulin resistance (IR). Compared with data collected at day 0 before gavage, in those given fructose, GSH declined ~77% but MDA, glucose, insulin and insulin resistance increased 30-70% by day 62 (P < 0.05). Compared with rats gavaged PC, in those given fructose we found decreased GSH (~-79%) but increased MDA (70%), glucose (50%), insulin (59%) and insulin resistance (80%). In rats gavaged PC with fructose, these values were only -68, 26, 33, 21 and 49%, respectively. The results suggest that PC may ameliorate effects of fructose induced metabolic syndrome in rabbits
Keyword: Metabolic syndrome, Fructose, Phosphatidylcholine, Oxidative stress, Hyperglycemia, Type 2 diabetes. Raw data provided.