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OJVRTM

 

Online Journal of Veterinary Research©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

Volume 28 (10): 733-746, 2024.

Fomecin lead antiviral for Hepatitis C.

 

R Shanmugam, K Mani, B Vijay Kumar.

 

Department of Botany, Karpagam College of Arts and science Coimbatore,India 1

 

ABSTRACT

 

Shanmugam R, Mani K, Vijay Kumar B., Fomecin antiviral for Hepatitis C, Onl J Vet Res., 28 (10): 733-746, 2024.  Non structural proteins of hepatitis C virus NS3-4A are required for polyprotein processing and replication and thus target against infection. We report natural lead compound as target by modeling NS3/4A complex docked with serine protease inhibitors.  Benzamidine with compounds isolated from fungal order Aphyllophorales.compounds that are related Benzamidine are docked with Discovery studio. Based on the docking scores the lead compound was selected against NS3/4A, following that adsorption and distribution were tested by ADME /TOX.

 

Key words: Hepatitis c virus, Docking, TSAR, and ADME/TOX, serine protease inhibitors.

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