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Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

Volume 26 (1):66-71, 2022.

Flunixin meglumine, pregnancy and heat stress in Holstein dairy cows


Behrang Ekrami DVM PhD1, Hamid Ghasemzadeh-Nava DVM PhD2, Parviz Tajik DVM PhD2

Mahmood Bolourchi DVM PhD2, Amin Tamadon DVM PhD3


Department(s) 1Clinical Sciences, Faculties of Veterinary Medicine, Science and Research Branch, Islamic Azad University, 2Clinical Sciences, University of Tehran, Tehran, 3Animal Health Management, Shiraz University & Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences Shiraz, Iran.




Ekrami B, Ghasemzadeh-Nava H, Tajik P, Bolourchi M, Tamadon A., Flunixin meglumine, pregnancy and heat stress in Holstein dairy cows, Onl J Vet Res., 26 (1):66-71, 2022 . We report effect of flunixin meglumine on pregnancy after artificial insemination in heat stressed dairy cows. Multiparous Holstein cow estrus and ovulation were synchronized with Select-OvSynch for artificial insemination. Groups of 40 cows each were injected intramuscularly 1.1 mg/kg flunixin meglumine daily from 2 to 5 (1) and 10 to 13 (2) days after insemination. Forty untreated cows were used as controls. Blood was taken at day 7 and 14 for plasma progesterone. Ultrasonographs were performed on same days for detection and evaluation of corpus luteum and for pregnancy at days 27-30. Mean daily temperature-humidity index varied 79-84 during trials and rectal temperatures were recorded daily. Plasma progesterone, corpus luteum or pregnancy did not differ between any group (P>0.05). Findings suggest flunixin meglumine injected in heat stressed cows, 2-5 or 10-13 days after insemination did not affect pregnancy.


Keywords: Flunixin meglumine, Heat stress, Pregnancy, Holstein dairy cow.