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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 22 (11):1077-1085, 2018.
Bioavailability, bioequivalence and pharmacokinetics of florfenicol in buffalo calves.
Pranvendra Kumar, A.H. Ahmad, Anu Rahal and K.P. Singh
Department of Veterinary Pharmacology & Toxicology, C.V.&A.Sc., G.B.P.U.A.&T., Pantnagar-263145 ,India.
Kumar P, Ahmad AH, Rahal A, Singh KP., Bioavailability, bioequivalence and pharmacokinetics of florfenicol in buffalo calves. 22 (11):1077-1085, 2018. The plasma levels of florfenicol were determined in buffalo calves following single intravenous (IV) and intramuscular (IM) doses of 20 mg/kg body weight. Blood was collected using indwelling jugular catheter at predetermined time intervals. Plasma was extracted and analyzed for florfenicol by reverse phase high performance liquid chromatography. Following IV and IM administration, florfenicol followed two-compartment and one-compartment open model, respectively. Subcutaneous route was found to possess a very low bioavailability of 27%. The elimination half-lives for IV and IM route were 2.38 and 2.88h, respectively. The pharmacokinetic variables derived in the study, indicated that intravenous dose of 13mg/kg may be clinically employed for treating the susceptible bacterial infections.
Key words: Florfenicol, pharmacokinetics, calves.