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OJVRTM
Online Journal of Veterinary Research©
Volume 26 (7): 519-528, 2022.
Inhibition of complement C5a Cteneocephalides
felis flea allergen dermatitis in mice
Ku Nurul Atiqah KA
DVM, Watanabe M DVM PhD, Farhana BN Bsc ,
Norhaifa G Bsc,
Hazwani
KN Bsc, Nashreq KN Bsc and Hezmee MNM DVM PhD
Faculty of Veterinary Medicine, Universiti
Putra Malaysia, 43400 Serdang, Selangor, Malaysia
43400 Serdang, Selangor, Malaysia.
Nurul Atiqah KA, Watanabe M, Farhana BN, Norhaifa G, Hazwani KN, Nashreq KN, Hezmee MNM, Inhibition of complement C5a Cteneocephalides felis flea
allergen dermatitis in mice, Onl J Vet Res., F26 (7): 519-528, 2022. Flea allergy dermatitis (FAD) in dogs is mostly induced by complement C5a from Ctenocephalides
felis. We report effect of complement inhibitor to inhibit activation of
C5a receptor allergic dermatitis in BALB/C mice. We compared results with prednisone and
assessed effects on tissue, hematology and
biochemical values. Four groups of 5 male and female mice each were injected 100µg/mouse flea antigen intramusculary and intradermally
and then injected daily for 3 days 0.1mg/kg complement C5 inhibitor (1) or 0.1mg/kg
prednisolone (2). Controls were given only flea antigen (3) or anti-histamine
(4). We found no effect on leucocytes, lymphocyte, neutrophils or eosinophils
but observed spongiosis and inflammation in epidermis.
Dermis of controls given only antigen measured ~48µm, complement inhibitor 42µm,
antihistamine 39µm and prednisone 26µm representing a difference of 46%. However
only controls injected flea antigen without treatment developed hyperplasia of epidermis
(P < 0.05)
Key Words: Ctenocephalides, complement C5,
prednisone, canine, mice, dermatitis.