2021-2032 All Rights Reserved. Online Journal of Veterinary Research . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the  before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJB publications. This article may be copied once but may not be, reproduced or  re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


OJVRTM

 Online Journal of Veterinary Research 

 Volume 25 (4): 312-326, 2021. 


In silico proteins of Flavobacterium columnare therapeutic candidates for columnaris disease in fish (Danio rerio).

 

S. Murali1, Sanath Kumar2, K. V. Rajendran3 and Shrinivas Jahageerdar4*

 

1,4 Fish Genetics and Biotechnology Division, CIFE, 2Fisheries Resource, Harvest and Post Harvest Management Division, CIFE, 3Aquatic Environment and Health Management Division, CIFE, Mumbai, India

 

ABSTRACT

 

Murali S, Kumar S, Rajendran KV, Jahageerdar S., In silico proteins of Flavobacterium columnare as therapeutic candidates for columnaris disease in fish, Onl J Vet Res., 25 (4): 312-326, 2021. Flavobacterium columnare causes columnaris disease in fish. We describe complete genome for F. columnare and host Danio rerio zebrafish to identify proteins essential for pathogen survival, but non-homologous to host as potential drug targets. We found 1826 proteins in F. columnare, non-homologous to proteins in zebrafish genome. Further screening revealed 238 database essential genes to F. columnare used to predict metabolic pathways with Kyoto Encyclopedia of Genes and Genomes. Of these, 39 were for genetic processing, 37 amino acid metabolism, 23 glycan biosynthesis, 22 metabolism of co-factors and vitamins, 16 carbohydrate metabolism, 16 environmental information processing, 14 nucleotide metabolism, 12 energy metabolism, 10 other amino acid synthesis, 6 lipid metabolism and 8 for cellular processes and signaling. Two essential outer membrane proteins were identified as potential drug targets.

 

Keywords: Flavobacterium columnare, columnaris disease, essential proteins, outer membrane proteins.


MAIN

 

 

FULL-TEXT (SUBSCRIBE OR PURCHASE TITLE)