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Online Journal of Veterinary Research©
Volume 25 (4): 312-326, 2021.
In silico proteins of Flavobacterium columnare therapeutic candidates for columnaris disease in fish (Danio rerio).
S. Murali1, Sanath Kumar2, K. V. Rajendran3 and Shrinivas Jahageerdar4*
1,4 Fish Genetics and Biotechnology Division, CIFE, 2Fisheries Resource, Harvest and Post Harvest Management Division, CIFE, 3Aquatic Environment and Health Management Division, CIFE, Mumbai, India
Murali S, Kumar S, Rajendran KV, Jahageerdar S., In silico proteins of Flavobacterium columnare as therapeutic candidates for columnaris disease in fish, Onl J Vet Res., 25 (4): 312-326, 2021. Flavobacterium columnare causes columnaris disease in fish. We describe complete genome for F. columnare and host Danio rerio zebrafish to identify proteins essential for pathogen survival, but non-homologous to host as potential drug targets. We found 1826 proteins in F. columnare, non-homologous to proteins in zebrafish genome. Further screening revealed 238 database essential genes to F. columnare used to predict metabolic pathways with Kyoto Encyclopedia of Genes and Genomes. Of these, 39 were for genetic processing, 37 amino acid metabolism, 23 glycan biosynthesis, 22 metabolism of co-factors and vitamins, 16 carbohydrate metabolism, 16 environmental information processing, 14 nucleotide metabolism, 12 energy metabolism, 10 other amino acid synthesis, 6 lipid metabolism and 8 for cellular processes and signaling. Two essential outer membrane proteins were identified as potential drug targets.
Keywords: Flavobacterium columnare, columnaris disease, essential proteins, outer membrane proteins.