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OJVRTM
Online Journal of Veterinary Research©
Volume 19(2): 116-123, 2015.
ABSTRACT
Hosseinpour D, Sajedianfard J, Nazifi S, Kavoosi G, Fathi M., Effect of earthworm Eisenia
fetida extract on blood and liver enzymes in Wistar rats, Onl J Vet Res., 19(2): 116-123, 2015. Groups of 6 adult male Wistar
rats were administered 1.25ml/kg saline IP (controls), E. Fetida extract oral 300µg/0.75/kg, E Fetida
IP 300ng/1.25 ml/kg) and heparin 180 IU/
230-270 g of body weight IP (controls), daily for 7 days. Rats were then sacrificed by ether and blood
collected by cardiac puncture. Oral and IP administration of E Fetida induced a decline in mean platelet volume (MPV)
compared with controls. There was no difference in MPV between rats given E. Fetida
extract IP or orally. Heparin had no effect on MPV. E fetida had no effect on prothrombin
time and partial thromboplastin time but prolonged bleeding time. Heparin and E Fetida
decreased alkaline phosphatase (ALP) activity but there was no difference
between alanine aminotransferase and aspartate aminotransferase between any group.
Keywords: Earthworm
Eisenia fetida extraction,
Hemostatic parameters, Liver enzymes, Wistar rat .
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