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OJVRTM
Online Journal of
Veterinary Research©
Volume 26 (8): 606-616, 2022.
Effects of molar teeth extraction on memory in Wistar rats.
Razieh Shojaeepour1, Fatemeh Jahanimoghadam1, Najmeh Pourgholamali1,
Saeedeh Shojaeepour2,
Hamid Sharifi3, 4
1-Kerman
Oral & Dental Research Center, Department of Pediatric Dentistry, Faculty
of Dentistry, University of Medical sciences, Kerman, 2- Faculty of
Veterinary Medicine, Shiraz University, 3- Department of Food Hygiene
and Public Health, Faculty of Veterinary Medicine, Shahid
Bahonar University of Kerman, 4- Research
center for Modeling in Health, Institute for Futures Studies in Health, Kerman
University of Medical Sciences
ABSTRACT
Shojaeepour
R, Jahanimoghadam F, Pourgholamali
N, Shojaeepour
S, Sharifi H., Effects of molar teeth extraction on
memory in Wistar rats, Onl
J Vet Res., 26 (8): 606-616, 2022. We
report effect of molar teeth extraction on memory in rats by Morris water maze
experiments. We extracted bilateral first, second and third maxillary molars
from 15 rats (1) left and right first, second and third left maxillary molars
and the first, second and third right mandibular from another group of 15 (2) and
15 controls without extractions (3). A day before the experiment, rats were
allowed to swim with video to record performance. Learning was performed daily
in 3 blocks of 30min sequential trials of 60s. Short and long memory was tested
by 60s and 24h swim and spatial memory by time spent, path length, latency,
path, speed, entry. Mean ± SD were compared by one-way ANOVA with Bonferroni
post hoc test. For learning tests, compared with controls, in rats with teeth
extractions, we recorded reduced (P < 0.01-0.04) ~11% target frequencies,
durations and ~16% path lengths. However, we found no effect on duration or
velocity or extractions patterns. For short term memory target frequency tests
we found ~25% reduction in rats subjected to extraction and long term memory
increased 7% but target duration declined ~13% (P < 0.05). Findings suggest
that molar teeth extraction may impair learning ability.
Key words:
Pattern of molar extraction; learning; memory; Morris water maze
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