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Online Journal of Veterinary Research


Volume 26 (8): 606-616, 2022.

Effects of molar teeth extraction on memory in Wistar rats.


Razieh Shojaeepour1, Fatemeh Jahanimoghadam1, Najmeh Pourgholamali1,

Saeedeh Shojaeepour2, Hamid Sharifi3, 4


1-Kerman Oral & Dental Research Center, Department of Pediatric Dentistry, Faculty of Dentistry, University of Medical sciences, Kerman, 2- Faculty of Veterinary Medicine, Shiraz University, 3- Department of Food Hygiene and Public Health, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, 4- Research center for Modeling in Health, Institute for Futures Studies in Health, Kerman University of Medical Sciences




Shojaeepour R, Jahanimoghadam F, Pourgholamali N, Shojaeepour S, Sharifi H., Effects of molar teeth extraction on memory in Wistar rats, Onl J Vet Res., 26 (8): 606-616, 2022. We report effect of molar teeth extraction on memory in rats by Morris water maze experiments. We extracted bilateral first, second and third maxillary molars from 15 rats (1) left and right first, second and third left maxillary molars and the first, second and third right mandibular from another group of 15 (2) and 15 controls without extractions (3). A day before the experiment, rats were allowed to swim with video to record performance. Learning was performed daily in 3 blocks of 30min sequential trials of 60s. Short and long memory was tested by 60s and 24h swim and spatial memory by time spent, path length, latency, path, speed, entry. Mean SD were compared by one-way ANOVA with Bonferroni post hoc test. For learning tests, compared with controls, in rats with teeth extractions, we recorded reduced (P < 0.01-0.04) ~11% target frequencies, durations and ~16% path lengths. However, we found no effect on duration or velocity or extractions patterns. For short term memory target frequency tests we found ~25% reduction in rats subjected to extraction and long term memory increased 7% but target duration declined ~13% (P < 0.05). Findings suggest that molar teeth extraction may impair learning ability.


Key words: Pattern of molar extraction; learning; memory; Morris water maze