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Online Journal of Veterinary Research

Volume 23 (4):278-284, 2019.

Effect of experimental Trypanosoma evansi infection on hematology, liver and spleen tissue in rabbits.


Azhar Ali Faraj.


Department of Parasitology, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq




Faraj AA., Effect of experimental Trypanosoma evansi infection on hematology, liver and spleen tissue in rabbits, Onl J Vet Res., 23 (4):278-284, 2019. Effect of single intraperitoneal 1x105l Trypanosoma evansi isolated from camels (Camelus dromedaus) injection on hematology, liver and spleen tissue in domestic rabbits is described. At 28 days, rabbits were sacrificed for hematology and histopathology. Compared with controls in infected rabbits hemoglobin, packed cell volume, red blood cells and mean corpuscular hemoglobin declined (P<0.05) ~10% whereas white blood cells increased ~20% and mean corpuscular hemoglobin ~8%. Neutrophils increased ~7%, monocytes 11% and eosinophils ~39% but lymphocytes declined ~17%. Alanine, aspartate transaminases and alkaline phosphatase increased 39-50% (P<0.05) compared with saline controls. In liver of infected rabbits there was vascular congestion, enlarged hepatocytes, absence of sinusoids, vacuolation and inflammatory cell infiltrate, and in spleen, depletion of lymphoid follicles with megakaryocytes.


Keywords: Rabbit, hematology, histopathology, Trypanosoma evansi.