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OJVRTM
Online Journal of Veterinary Research©
Volume 23 (4):278-284, 2019.
Effect of experimental Trypanosoma evansi infection
on hematology, liver and spleen tissue in rabbits.
Azhar
Ali Faraj.
Department of
Parasitology, College of Veterinary Medicine, University of Baghdad, Baghdad,
Iraq
ABSTRACT
Faraj AA., Effect of experimental Trypanosoma evansi
infection on hematology, liver and spleen tissue in rabbits, Onl J Vet Res., 23 (4):278-284, 2019. Effect of single intraperitoneal
1x105µl Trypanosoma evansi isolated from camels (Camelus
dromedaus) injection on hematology,
liver and spleen tissue in domestic rabbits is described. At 28 days, rabbits were sacrificed for
hematology and histopathology. Compared with controls in infected rabbits hemoglobin,
packed cell volume, red blood cells and mean
corpuscular hemoglobin declined (P<0.05) ~10% whereas white blood cells increased
~20% and mean corpuscular hemoglobin ~8%. Neutrophils increased ~7%, monocytes 11% and
eosinophils ~39% but lymphocytes declined ~17%. Alanine, aspartate transaminases
and alkaline phosphatase increased 39-50% (P<0.05) compared with saline
controls. In liver of infected rabbits there was vascular congestion, enlarged
hepatocytes, absence of sinusoids, vacuolation and inflammatory
cell infiltrate, and in spleen, depletion of lymphoid follicles with megakaryocytes.
Keywords: Rabbit, hematology, histopathology,
Trypanosoma evansi.
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