1994-2019 All Rights Reserved. Online Journal of Veterinary Research. You may not store
these pages in any form except for your own personal use. All other usage or
distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the
before mentioned must be gained in writing from the publisher. This
article is exclusively copyrighted in its entirety to OJVR publications. This
article may be copied once but may not be, reproduced or re-transmitted without
the express permission of the editors.
OJVRTM
Online Journal of Veterinary
Research©
Volume 22 (4):322-329, 2018.
Effect of Eruca sativa on phosphoric acid induced renal
toxicity in rabbits.
Dina Saadoon Dheyab
Lecturer –Department of Physiology and
Pharmacology, College of
Veterinary Medicine –University of Baghdad, Iraq.
ABSTRACT
Dheyab DS., Effect of Eruca sativa on phosphoric
acid induced renal toxicity in rabbits. Onl J Vet
Res., 22 (4):322-, 2018. Author reports effect of aqueous extract of Eruca sativa leaves on serum urea, uric acid,
protein and kidney tissue in rabbits gavaged 1/10
lethal dose of 1350mg/dl phosphoric acid with or without 250mg/kg aqueous Eruca sativa daily for 30 days. Five controls
were given only food and water. At day 30, fasting heart blood samples were
taken. In rabbits gavaged phosphoric acid,
serum urea values were 80.6mg/dl, uric acid 2.53mg/dl and
globulin 2.75 mg/dl, all higher (P < 0.05) than same values in other groups.
However, total serum protein (4.71mg/dl) was lowest in those given only
phosphoric acid (P < 0.05). In rabbits gavaged Eruca sativa with phosphoric acid serum urea
was 43.00mg/dl, uric acid 1.64mg/dl, globulin 1.15mg/dl but serum proteins
remained stable (P < 0.05) to 7.62mg/dl. Values in rabbits given only E. sativa extract were similar to
controls and those given the extract with phosphoric acid. In rabbits gavaged only phosphoric
acid, microscopy revealed acidophilic cytoplasm of cells in renal cortex and
medulla. Glomeruli showed necrosis with atrophy of the glomerular tuft. In the
medulla, there was degeneration in epithelial cells of the renal tubules with
necrosis and cast formation. In rabbits gavaged Eruca sativa extract with or without
phosphoric acid kidneys appeared normal. Findings suggest a protective effect
of Eruca sativa on phosphoric acid toxicity in
rabbits.
Keywords:
phosphoric acid, Eruca sativa, urea,
uric acid, total serum protein, globulin, albumin. Raw data supplied.
FULL-TEXT
(SUBSCRIPTION OR PURCHASE TITLE $25USD)