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OJVRTM

Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994
ISSN 1328-925X

 

Volume 26 (9): 661-672, 2022.

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In silico prediction for epitope adhesins of Staphylococcus aureus mastitis.

 

Garima Bajetha, Sarika and Anil Rai

 

Indian Agriculture Statistics Research Institute, Pusa Campus, New Delhi, India.

 

ABSTRACT

 

Sarika BG, Rai A., In silico prediction for epitope adhesins of Staphylococcus aureus mastitis, Onl J Vet Res., 26 (9): 661-672, 2022. Pheno-genotypes of Staphylococcus aureus which adhere to extracellular matrix and plasma proteins are involved in pathogenesis of orthopaedic-device related mastitis. To develop peptide vaccines for extracting adhesins from S. aureus cell wall we used In silico sequence, structure, QSAR, simulation and folding analysis to predict antigenic B-cell derived T-cell epitopes to induce B and T-cell immunity. We found T-epitopes IRKLGVGIA from Immunoglobulin G-binding protein A, IEFLEVVGL from Conserved virulence factor B, IISLGALAVASS from Staphylocoagulase and LLVIRTKGTIA from Alpha-Hemolysin antigens able to interact with human HLA alleles DRB1*0101 and 0401. Findings suggest that these epitopes may induce both the B-cell and T-cell mediated immune responses.

 

Key words: - Staphylococcus aureus, epitopes, mastitis, vaccines, immunity.


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