©1994-2009 All Rights Reserved. Online Journal
of Veterinary Research. You may not store these pages in any form except
for your own personal use. All other usage or distribution is illegal under
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OJVRTM
Online Journal of Veterinary Research©
Volume 7: 99-105, 2003.
Evaluation of the efficacy of eformoterol on exercise-induced pulmonary hemorrhage in
training thoroughbred horses.
Ladaga GJB1,2,
Pont Lezica F1,
Ulloa F1, de Erausquin GA1,3, Ruzzante G1, Negrelli
C1 del Carril R1
INCA Group1, Buenos Aires, Argentina; Laboratorio
Fundación2, Buenos Aires, Argentina; and Washington University School of
Medicine3, St Louis, Missouri. Address for correspondence: Gabriel A. de Erausquin, MD, PhD Washington University School of
Medicine,
ABSTRACT
Ladaga GJB, Pont Lezica F, Ulloa F, de Erausquin GA, Ruzzante G, Negrelli C, del Carril R . Evaluation of the efficacy of eformoterol on exercise-induced pulmonary hemorrhage in
training thoroughbred horses. Online J Vet Res 7: 99-105, 2003.
Exercise-induced pulmonary hemorrhage
(EIPH) is a major medical problem in competitive horses, with economic effects
on breeders and trainers. The pathophysiology of EIPH
is poorly understood and current pharmacological treatment is inadequate. Eformoterol is a b2 adrenergic agonist with putative
vascular, bronchial, and anti-inflamatory effects. A
blind trial of intramuscular eformoterol in thoroughbred
horses with EIPH during competitive training was performed during 180 training
sessions in 29 horses (2-4 years-old, 400-500 kg). The first 90 sessions were
used to classify horses with endoscopically confirmed
EIPH in either light (LB) or heavy (HB) bleeders. Training sessions (speed
15.57-17.73 m/sec, 600-1800 m) performed 2 h after receiving 0.040 (LB), or
0.080 (HB) mg eformoterol; were followed by physical
evaluation at 40 min and endoscopy at 60 min after
completion. Following eformoterol, no epistaxis was observed in either group. Endoscopically,
95 % of LB had less than 1+ bleeding, and none had greater than 2+ hemorrhage. In HB, 85% had less than 1+ bleeding, and only
one animal showed greater than 2+ hemorrhage.
Performance was assessed as "optimal" by blind jockeys and trainers.
Vital signs returned to baseline 40 min after the training session. The
findings suggest that eformeterol given at the above
doses did not induce abnormalities in training horses.
KEYWORDS: eformoterol, thoroughbred, exercise-induced pulmonary
hemorrhage.
©1994-2009 All Rights Reserved. Online Journal
of Veterinary Research. You may not store these pages in any form except
for your own personal use. All other usage or distribution is illegal under
international copyright treaties. Permission to use any of
these pages in any other way besides the before mentioned must be gained in
writing from the publisher. This article is exclusively copyrighted in
its entirety to OJVR publications. This article may be copied once but may not
be, reproduced or re-transmitted without the express permission of the editors.