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OJVRTM
Online Journal of
Veterinary Research©
Volume 7 :
99-105, 2003. Redacted 2018.
Effect of eformoterol on exercise-induced pulmonary hemorrhage in
training thoroughbred horses.
Ladaga
GJB1,2, Pont Lezica
F1, Ulloa F1, de Erausquin GA1,3,
Ruzzante G1, Negrelli
C1 del Carril R1.
INCA Group1, Buenos Aires,
Argentina; Laboratorio Fundación2, Buenos Aires,
Argentina; and Washington University School of Medicine3, St Louis, Missouri.
Address for correspondence: Gabriel A. de Erausquin,
MD, PhD Washington University School of Medicine, 660 S. Euclid Ave, Campus Box
8134, St. Louis, MO 63110 e-mail: erausquing@neuro.wustl.edu
ABSTRACT
Ladaga GJB,
Pont Lezica F, Ulloa F, de Erausquin
GA, Ruzzante G, Negrelli C,
del Carril R . Evaluation of the
efficacy of eformoterol on Exercise-induced Pulmonary
Hemorrhage in training thoruoughbred horses. Onl J Vet Res., 7:99-105, 2003. Exercise-induced pulmonary
hemorrhage (EIPH) is a major medical problem in competitive horses, with
economic effects on breeders and trainers. The pathophysiology of EIPH is
poorly understood and current pharmacological treatment is inadequate. Eformoterol is a b2 adrenergic agonist with putative
vascular, bronchial, and anti-inflammatory effects. A blind trial of
intramuscular eformoterol in thoroughbred horses with
EIPH during competitive training was performed during 180 training sessions in
29 horses (2-4 years-old, 400-500 kg). The first 90 sessions were used to classify
horses with endoscopically confirmed EIPH in either light (LB) or heavy (HB)
bleeders. Training sessions (speed 15.57-17.73 m/sec, 600-1800 m) performed 2 h
after receiving 0.040 (LB), or 0.080 (HB) mg eformoterol;
were followed by physical evaluation at 40 min and endoscopy at 60 min after
completion. Following eformoterol, no epistaxis was
observed in either group. Endoscopically, 95 % of LB had less than 1+ bleeding,
and none had greater than 2+ hemorrhage. In HB, 85%
had less than 1+ bleeding, and only one animal showed greater than 2+ hemorrhage. Performance was assessed as "optimal"
by blind jockeys and trainers. Vital signs returned to baseline 40 min after
the training session. The findings suggest that eformeterol
given at the above doses did not induce abnormalities in training horses.
KEYWORDS: eformoterol, thoroughbred,
exercise-induced pulmonary hemorrhage.
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