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OJVRTM
Online Journal of Veterinary Research©
Volume 24
(6):356-365, 2020.
Histopathology and F1L gene sequence analysis of
contagious ecthyma virus in sheep and goats.
Davari SA1 (DVM, PhD), Sayyari M2*
(DVM, PhD), Mohammadi A2 (DVM, PhD)
1Department(s) of Pathobiology, Faculties
of Veterinary Medicine, Zabol University, Zabol, 2Shiraz University, Shiraz, Iran
ABSTRACT
Davari SA, Sayyari
M, Mohammadi A., Histopathology and F1L gene sequence analysis of contagious ecthyma virus in sheep and goats, Onl
J Vet Res., 24 (6):356-365, 2020.
Contagious
ecthyma, also known as Orf,
is a common viral skin disease of sheep and goats caused by Parapoxvirus.
We describe pathology and Orf virus F1L gene sequence by PCR from sheep
and goats. Tissue samples revealed epidermal hyperplasia with prominent rete
ridges, hydropic degeneration of the necrotic keratinocytes, eosinophilic intracytoplasmic
inclusion bodies in vacuolated cells and subcorneal
pustules. By PCR we found ~50% positive to the virus of which 10 were sequenced
for Orf-059-Shiraz strain recorded in GeneBank for
phylogenetic analysis and suggested that this gene is highly conserved.
Key words: Contagious ecthyma,
Histopathology, Molecular analysis.
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