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OJVRTM
Online Journal of Veterinary Research©
Volume 21(6):308-316, 2017.
Effect
of hydralazine on doxorubicin-induced testicular toxicity and sperm disorders
in NMRI mice
Asadollahi Negar, Azadbakht
Mehri.
Department of Biology, Faculty of Sciences, Razi
University, Kermanshah, Iran.
ABSTRACT
Negar A, Mehri A.,
Effect of hydralazine on doxorubicin-induced testicular toxicity and sperm disorders in NMRI
mice, Onl J Vet Res., 21(6):308-316,
2017. Groups
of 8 male NMRI mice each, aged 6 to 8 weeks were given 3mg/kg intraperitoneal injection (IP)
doxorubicin on days 7, 14 and 21, 5mg/kg, hydrazaline
IP for 21 days and hydralazine IP 7 days before doxorubicin at days 7, 14 and
21. Controls were injected saline IP. Mice were sacrificed by cervical
dislocation 28 or 64 days after the 1st treatment. Results suggested
that doxorubicin reduced sperm count, viability, motility, spermatogonia,
primary spermatocyte, spermatid and sertoli cells
with elevated abnormal spermatozoids (P<0.05). Diameters of seminiferous
tubular and germinal epithelial thickness decreased by morphometric assessment
(P<0.05). In mice given hydrazaline after
doxorubicin, sperm quantity and quality returned to normal. Results suggest
that hydralazine may affect doxorubicin-induced testicular toxicity in mice.
Key words:
Doxorubicin, Hydralazine, Testes, Sperm, Mice
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