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OJVRTM
Online Journal of Veterinary Research©
(Including
Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 29 (1):
46-56, 2025.
Effect of Metoprolol and Troxerutin on
cardiotoxicity induced by doxorubicin in male Wistar
rats
Teeba Ghassan,
Fouad Zeidan Hamzah.
Department of Physiology, Biochemistry and Pharmacology,
Faculty of Veterinary Medicine, University of Kufa,
Najaf Province, Iraq.
ABSTRACT
Ghassan T, Hamzah FZ., Effect of Metoprolol and Troxerutin on
cardiotoxicity induced by doxorubicin in Wistar rats,
Onl J Vet Res., 29 (1): 46-56, 2025. Doxorubicin
(DOX) can induce cardiotoxicity through oxidative stress. Metoprolol (MET)
beta-blocker reduces heart oxygen demand whereas troxerutin
(P4) a flavonoid scavenges reactive oxygen species. Effect of combining both
drugs on cardiotoxicity of DOX remains unknown. Four groups of 10 male Wistar rats each were injected 3mg/kg DOX intraperitoaneally (IP) for cumulative dose of 12mg/kg
(1), gavaged
300mg/kg P4 four weeks before 300mg/kg DOX (2), gavaged
10mg/kg MET 4 weeks before 300mg/kg DOX (3) and gavaged
10mg/kg MET with 300mg/kg P4 4 weeks before 300mg/kg DOX (4). Ten controls were
given saline (5). We then determined cardiac troponins (cTnI
and cTnC) and oxidation marker
8-Hydroxy-deoxyguanosine (80HdG) by ELISA and microscopy of heart tissues.
Compared with controls cardiac troponin 1 increased (P < 0.05) 68% in rats
given DOX, 58% with P4 and 41% given MET + DOX 3 but only ( P > 0.05 NS) 14%
with MET, P4 and DOX. Corresponding values for troponin C were 83%, 71% and 60
%(P < 0.05) but only 13% when combined (P >
0.05) and for 80HdG 73%, 63%, 52% and 24%. Microscopy revealed extensive
necrosis and fibrosis in heart tissue of rats given DOX without MET or P4.
Keywords: Cancer, Cardiotoxicity,
Doxorubicin, Metoprolol, Troxerutin.
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