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OJVRTM
Online Journal of Veterinary Research©
Volume 20(5):345-352, 2016.
Effect of
doxapram on isoflurane anaesthesia recovery in dogs.
Soroush
Sabiza⃰ DVM, DVSC; Hadi Naddaf DVM, DVSc; Ali Baniadam DVM, DVSc;
Bahman Mosallanejad DVM, DVSc.
Deparment of
Clinical Science, Faculty of Veterinary Medicine, Shahid Chamran University of
Ahvaz, Ahvaz, Iran
ABSTRACT
Sabiza S, Naddaf H, Baniadam A, Mosallanejad B.,
Effect of doxapram on recovery from isoflurane anesthesia in dogs, Onl J Vet
Res., 20(5):345-352, 2016. We report
effect of intravenous doxapram on recovery
from isoflurane anesthesia in dog. Twelve
clinically healthy male mixed dogs were sedated by acepromazine and 30 min later induced by propofol titration maintained 30min by isoflurane. At end of anesthesia 2mg/kg doxapram was injected IV to 6 dogs. Another 6
controls were injected IV saline with same volume as treated dogs. Physiological parameters were measured 30 min after sedation and 5, 10, 20, 30, 40
and 50min after induction of anesthesia and recovery. Times of endotracheal extubation, first head lifting, first sternal recumbency and duration and quality of recovery were
registered. Findings suggested that doxapram injected
IV by the end of anesthesia hastened recovery about 15 min (p<0.05).
Heart rate and blood pressure increased but end tidal CO2
decreased (p<0.05) with doxapram. Doxapram may accelerate recovery following isoflurane anesthesia
in dogs.
Key words: doxapram, recovery, isoflurane, dog.
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