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OJVRTM
Online Journal of Veterinary Research©
Volume 18(8): 688-695, 2014.
Morphological and immuno-histochemical
characterization of five phyllodes mammary gland
tumors in dogs
Araújo MR1, Damasceno KA1, Gamba CO1,
Campos CB2, Campos LC1, Reis DC1, Souza CM1,
Cassali GD1*
1Comparative
Pathology Laboratory, Institute of Biological Sciences, Federal University of
Minas Gerais – UFMG, Brazil; 2Postgraduate
Program of Veterinary Medicine, School of Agricultural and Veterinary Sciences
of the Sao Paulo State University (FCAV/UNESP) – Jaboticabal
Campus Via de Acesso Prof. Paulo Donato Castellane s/n, PO Box 14884-900, Phone +551632092600, Jaboticabal, Brazil *Corresponding author: Geovanni Dantas Cassali. Email: cassalig@icb.ufmg.br
ABSTRACT
Araújo MR, Damasceno KA, Gamba
CO, Campos CB, Campos LC, Reis DC, Souza CM, Cassali
GD., Morphological and immuno-histochemical characterization of five phyllodes mammary gland tumors in dogs, Onl
J Vet Res.,
18(8): 688-695, 2014. In bitches mammary tumors represent 52% of all
neoplasms. The phyllodes tumor is a rare
fibro-epithelial neoplasm found in humans characterized by epithelial and
mesenchymal (stromal) cell proliferation creating elaborate leaf-like
structures. Morphological and
immune-histochemical characteristics in 5 canine phyllodes tumors are described. Four benign and one
malignant phyllodes tumors
were diagnosed. Epithelial and stromal tumor
cells were positive for cytokeratin AE1AE3 and vimentin, respectively, and all
were positive for estrogen and progesterone receptors. Benign tumors were negative for p63 whereas
the malignant tumor was positive for p63. Cell proliferation index was <1%
in benign tumors tissue but 69.5% in the malignant one. All tumors were
negative for c-KIT. The morphological and immune-phenotypical aspects observed
in this study suggest similarities between phyllodes
tumors diagnosed in women and in bitches. However, new studies are necessary to
enhance knowledge regarding the biological behavior of these neoplasms.
Key words: dog; immunohistochemistry;
mammary neoplasm; phyllodes tumor.
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