Volume 23 (6):555-567, 2019.
Effect of erythromycin on pharmacokinetics of Amlodipine in hypertensive rabbits.
Rana M Ahmad and Orooba MS Ibrahim.
Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Baghdad, Iraq.
Ahmad RM, Ibrahim OMS., Effect of erythromycin on pharmacokinetics of amlodipine in hypertensive rabbits, Onl J Vet Res., 23 (6):555-567, 2019. Two groups of 6 cannulated rabbits each, were given oral 0.21mg/kg amlodipine once with or without 22mg/kg erythromycin every 6 hours for 24 hours. Another two groups of 6 normo and hypertensive rabbits were used as controls. Blood was taken at 0, 1 and intervals to 144 hours for measurement of amlodipine and erythromycin by spectrophotometry. Blood pressure was measured at intervals with cuffed Doppler ultra sound transducer. Bioavailability of amlopidine was higher (p < 0.05) given with erythromycin with Cmax of 4.40 ug/ml at 9h and AUC 125 ug/ml/h compared with 2.03 μg/ml and 96.1 μg/ml/h in rabbits given only amlopidine. We found reduced clearance (Cl) of 57.3L/kg/h and increased distribution (Vd) 5390L/kg for amlopidine given with erythromycin compared with those administered amlopidine only ( Cl 74.31 L/kg/hr and AUC 3715 L/kg) respectively. We found large reductions in blood pressure in rabbits given aminolidine with erythromycin. These results suggest that increased biovailabilty of aminolipine due to erythromycin might decrease blood pressure further in rabbits.
Keyword: pharmacokinetic, amlodipine, erythromycin, Interaction, hypertension. Raw data received