2021-2032 All Rights Reserved. Online Journal of Veterinary Research.  You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to publications. This article may be copied once but may not be, reproduced or  re-transmitted without the express permission of the editors. Linking: To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


Online Journal of Veterinary Research


25 (3): 197-206, 2021.

Effects of diminazine on alamycin and creatinine clearance in goats


Amer Aziza M, Youssef AS, Galal AM.


Department of Pharmacology, Faculty of Veterinary Medicine Cairo University, Giza, Egypt




Amer Aziza M, Youssef AS, Galal AM., Effect of diminazine on alamycine and creatinine clearance in goats. Onl J Vet Res., 25 (3): 197-206, 2021. The effect of diminazine on serum and urine clearance of long acting alamycin, creatinine and creatine kinase in groups of 5 lactating goats each was determined. One group was injected 30mg/kg alamycin IM. Another group was injected 3.5 mg/kg diminazene aceturate IM 2 hours before 30mg/kg alamycin IM. To determine clearance, the same goats were injected a bolus of alamycin IV after a washout period. Alamycin persisted in urine samples up to 96 hours with therapeutic effect over MIC, of Cmax 1.23 0.062 at 24h and 1.24 0.079 g/ml at 8h after IM injection, whereas 1 hr after IV bolus, reached 1.46 0.012 in controls and 1.5 0.033 g/ml in goats given diminazine. Serum and urine creatinine concentration and cumulative endogenous creatinine and OTC clearance were higher in goats given diminazine (P < 0.01 to P < 0. 0001). Higher Cmax, shorter Tmax and higher AUC of serum CK activity was found in goats given diminazine.


Keywords: OTC, diminazine aceturate, clearance, creatine kinase.