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Online Journal of Veterinary Research

Volume 23 (1):15-22, 2019.

Influence of hydroxyapatite on fracture healing of diabetic rats: a biomechanical and radiographic study.


Moslemi HR2 DVM, Meimandi Parizi A1 DVM PhD, Jelodar GA1 DVM PhD, Khodakaramtafti A1 DVM PhD.


1School of Veterinary Medicine, Shiraz University, Shiraz, Iran ; 2Islamic Azad University, Garmsar Branch, Garmsar, Iran.




Moslemi HR, Meimandi Parizi A, Jelodar GA, Khodakaramtafti., Influence of hydroxyapatite on fracture healing of diabetic rats: a biomechanical and radiographic study, Onl J Vet Res., 23 (1): 15-22, 2019. Fracture healing is a process of restoring structural and biological properties of injured bone. Osteopenia is one of the most common complications in diabetic patients. This condition causes increased healing time with a concomitant increase in delayed unions and non-unions. This study was conducted to evaluate the effect of hydroxyapatite (HA) on fracture healing of diabetic rats by biomechanical and radiographic methods. Eighteen adult male rats were randomly divided into three groups. Diabetes was chemically induced in 2 groups. After 2 weeks, all the rats were anesthetized and a transverse osteotomy of the right radius was performed under aseptic conditions. In one diabetic and one non-diabetic group, the osteotomy gap was filled with HA while the second diabetic group did not receive HA. All the rats were sacrificed 5 weeks after operation, the radial bones harvested and prepared for the three-point bending test. The results of biomechanical test revealed a significant positive effect of HA on fracture healing of HA treated groups. The diabetic rats that did not receive HA, exhibited inferior biomechanical properties in comparison with HA treated groups. The latter group showed less callus formation at the fracture site in comparison to the other two groups. The fracture line removal and remodeling of osteotomy site of this group was less than other groups.


Key words: hydroxyapatite, fracture healing, biomechanics, radiography, diabetic rat.