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OJVRTM
Online Journal of Veterinary Research©
Volume 23 (1):15-22, 2019.
Influence of hydroxyapatite on fracture healing of
diabetic rats: a biomechanical and radiographic study.
Moslemi HR2 DVM, Meimandi Parizi A1
DVM PhD, Jelodar GA1 DVM PhD,
Khodakaramtafti A1 DVM PhD.
1School of Veterinary Medicine, Shiraz
University, Shiraz, Iran ; 2Islamic Azad University, Garmsar Branch,
Garmsar, Iran.
ABSTRACT
Moslemi HR, Meimandi Parizi A, Jelodar GA, Khodakaramtafti., Influence of hydroxyapatite on fracture
healing of diabetic rats: a biomechanical and radiographic study, Onl J Vet
Res., 23 (1): 15-22, 2019. Fracture
healing is a process of restoring structural and biological properties of
injured bone. Osteopenia is one of the most common complications in diabetic
patients. This condition causes increased healing time with a concomitant
increase in delayed unions and non-unions. This study was conducted to evaluate
the effect of hydroxyapatite (HA) on fracture healing of diabetic rats by
biomechanical and radiographic methods. Eighteen adult male rats were randomly
divided into three groups. Diabetes was chemically induced in 2 groups. After 2
weeks, all the rats were anesthetized and a transverse osteotomy of the right
radius was performed under aseptic conditions. In one diabetic and one
non-diabetic group, the osteotomy gap was filled with HA while the second
diabetic group did not receive HA. All the rats were sacrificed 5 weeks after
operation, the radial bones harvested and prepared for the three-point bending
test. The results of biomechanical test revealed a significant positive effect
of HA on fracture healing of HA treated groups. The diabetic rats that did not
receive HA, exhibited inferior biomechanical properties in comparison with HA
treated groups. The latter group showed less callus formation at the fracture
site in comparison to the other two groups. The fracture line removal and
remodeling of osteotomy site of this group was less than other groups.
Key words: hydroxyapatite, fracture
healing, biomechanics, radiography, diabetic rat.
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