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OJVRTM
Online Journal of Veterinary Research©
Volume 20(11):720-727, 2016.
Effect of dextromethorphan NMDA antagonist on ulcerative colitis
in mice
Ehsan Motaghi1, Valiollah Hajhashemi1, Parvin Mahzouni2, Mohsen Minaiyan1,*.
1Department of Pharmacology and Isfahan Pharmaceutical Sciences
Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan
University of Medical Sciences, Isfahan, 2Department of
Clinical Pathology, School of Medicine, Isfahan University of Medical Sciences,
Isfahan, Iran.
ABSTRACT
Motaghi E, Hajhashemi V, Mahzouni P, Minaiyan M.,
Effect of dextromethorphan NMDA antagonist on ulcerative colitis in mice, Onl J Vet Res., 20(11):720-727, 2016. Dextromethorphan is a non-opioid NMDA receptor antagonist with
anti-inflammatory properties. Effect of dextromethorphan on experimental
ulcerative colitis in groups of 6 mice each is described. Mice were given
intraperitoneal 20, 60, and 100 mg/kg/day, dextromethorphan 24h before
induction of colitis and daily 4 days after. Other groups were fed 60 mg/kg and
2g/kg L-glutamic acid as glutamate receptor agonist controls. Ulcerative
colitis was induced by intracolonic instillation of 40mg/kg trinitrobenzoic sulfonic acid (TNBS). Mice given
dexamethasone 1mg/kg were used as reference controls. All animals received
intra-rectal TNBS except sham controls. Colitis and sham controls were given
normal saline IP in equal volume. Mice were sacrificed by anesthesia 4 days
after induction of colitis. Compared with controls, dextromethorphan improved body weight loss, colonic weight,
macroscopic colitis score and colonic myeloperoxidase (MPO) activity values.
However, there was no significant difference in these parameters between medium
and high doses of dextromethorphan.
Key words: Dextromethorphan, Ulcerative colitis, NMDA receptors,
TNBS, Rats
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