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OJVRTM
Online Journal of Veterinary Research©
Volume 19(2):
66-73, 2015. Redacted 2018.
Serum electrolyte levels
after dexamethasone and isoflupredone administration
in normal Holstein calves.
Aliasghar Chalmeh, Mehrdad Pourjafar, Saeed Nazifi,
Mohamad Reza Zarei, Mojtaba
Limoei
School of Veterinary Medicine, Shiraz
University, Shiraz, Iran
ABSTRACT
Chalmeh A, PourjafarM,
Nazifi S, Reza Zarei M, Limoei M., Serum electrolyte levels after dexamethasone and
isoflupredone administration in normal Holstein
calves, Onl J Vet Res., 19(2):
66-73, 2015. Two groups of 5, 6-10 month healthy Holstein calves
each, were injected 1mg/kg dexamethasone sodium phosphate or isoflupredone acetate IM, respectively, on 2 consecutive
days. Blood samples were taken at administration (controls) and days 2, 3, 5
and 7. Significant decreases were observed in serum potassium, chloride,
calcium and phosphorus concentrations after isoflupedone
administration compared with day 0 control values. The same electrolytes levels
were lower in calves given isoflupredone compared
with those administered dexamethazone. Neither drug
appeared to affect sodium or magnesium levels in any group. Changes in serum
electrolyte levels following isoflupredone
administration may be due to greater mineralocorticoid effects compared with
dexamethasone.
Keywords: electrolyte imbalance,
mineralocorticoid activity, isoflupredone,
dexamethasone.
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