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Online Journal of Veterinary Research©
Volume 23 (10):1007-1016, 2019.
Sutureless amniotic membrane 2-Octyl cyanoacrylate patch for treatment of corneal alkali burn in dogs.
Abbaszadeh M1, Aldavood SJ1, Foroutan A.R2, Azizzadeh M3 , Izadi SS1, Selk Ghaffari M4.
1Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran. 2Department of Clinical Sciences, Eye Research Center, Iran university of Medical Sciences, Tehran. 3Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi University, Mashhad. 4Department of Clinical Sciences, Faculty of Veterinary Medicine, Islamic Azad University-Karaj Branch, Karaj, Iran. Work was completed at internal medicine research center, Department of Clinical Sciences, University of Tehran, Iran and was not supported by any grant.
Abbaszadeh M, Aldavood SJ, Foroutan AR, Azizzadeh M, Izadi SS, Selk Ghaffari M., Sutureless amniotic membrane 2-Octyl cyanoacrylate patch for treatment of corneal alkali burn in dogs, Onl J Vet Res., Volume 23 (10):1007-1016, 2019. Authors describe surgery and clinical outcomes of a tissue adhesive 2-Octyl cyanoacrylate (Dermabond) amniotic membrane patch for treatment of experimental corneal burn in dogs. Alkali wounds were inflicted on the central corneas of dogs under anesthesia by applying a round filter paper, 6.0 mm diameter, soaked in 1 N NaOH for 60 sec unilaterally on each eye. Three groups of 5 dogs each were uncovered controls (1), covered by amniotic membrane with amniotic cell membrane sutured to cornea with 10–0 nylon (2), or covered with amniotic membrane with 2-Octyl cyanoacrylate (3). Operating time, clinical outcome, epithelial defects, opacity, blepharospasm, membrane retention, vascularization and ocular discharges were monitored 21 days. Surgery time in dogs treated with adhesive membrane was less than those sutured (P<0.001). Membrane persisted longer (P < 0.023) and cornea healed faster with adhesive (P = 0.038). However, we found no differences with corneal opacity or blepharospasm. Ocular discharges were also less in dogs treated with adhesive membrane and none of the corneas stained.
Key words: Dog, Amniotic membrane, 2-Octyl cyanoacrylate, Dermabond, corneal alkali burn.