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OJVRTM
Online
Journal of Veterinary Research©
Volume 19(6): 424-435, 2015.
Effect of
C5aR antagonist on histopathological and blood parameters in female BALB mice
following chlorhexidine-induced contact dermatitis.
Farhana BN BSc1, Siong JJ
DVM, Noordin MM DVM PhD2 and Hezmee MNM DVM PhD1
1Preclinical Sciences, 2Veterinary
Pathology and Microbiology,
Faculty of Veterinary Medicine, Universiti
Putra Malaysia Selangor, Malaysia.
ABSTRACT
Farhana
BN, Siong JJ, Noordin MM, Hezmee MNM, Effect of C5aR antagonist on histopathological
and blood parameters in mice following chlorhexidine-induced contact dermatitis
in mice, Onl J Vet Res., 19(6): 424-435, 2015. Chlorhexidine
is a commonly used antiseptic agent which can induce hypersensitivity in
humans. Whether chlorhexidine produces hypersensitivity in mice is unclear.
Four groups of 6 mice each were injected
dexamethasone, histamil, complement component
C5a receptor antagonist PMX205, or saline (controls). Blood and skin samples
were taken, and serum IgE for allergy reaction was
detected by ELISA. Chlorhexidine induced contact dermatitis in all mice.
Results suggest C5aR antagonist can reduce contact dermatitis by chlorhexidine
compared with anti-histamine and corticosteroids. Blood parameters did not show
significant changes compared with controls in any group. C5aR antagonists may
have an effect on chlorhexidine-induced contact dermatitis in mice but
microscopy assessments should be interpreted with caution as only 2 mice from
each group were assessed.
Keywords: chlorhexidine, chlorhexidine-induced
contact dermatitis, C5aR antagonist
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