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OJVRTM
Online Journal of
Veterinary Research©
Volume 19(2): 90-101,
2015.
Determination of
optimum dosage schedules of danofloxacin following
two extravascular routes of administration in buffalo calves (Bubalus bubalis)
1Ravinder Kaur Sappal, BVSc, MVSc; 2*Pritam Kaur Sidhu, BVSc,
MVSc, PhD; 3Rakesh Kumar Chaudhary, BVSc, MVSc, PhD; 4Harpal
Singh Sandhu, BVSc, MVSc, PhD.
1,3,4 Department
of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Science University, 2Animal Disease Research Centre, College of Veterinary
Science, Guru Angad Dev Veterinary and Animal Science
University, Ludhiana 141004, Punjab, India.
ABSTRACT
Sappal RK, Sidhu PK, Chaudhary RK, Sandhu HS., Determination
of optimum dosage schedules of danofloxacin following
two extravascular routes of administration in buffalo calves (Bubalus bubalis), Onl J Vet Res., 19(2): 90-101,
2015. We report rational
dosage schedules for danofloxacin by linking in vitro PD data with in vivo PK profile of buffalo calves.
The PK of danofloxacin was evaluated in eight healthy
male buffalo calves following intramuscular (IM) and subcutaneous (SC)
administration of danofloxacin at the dose rate of
1.25 mg/kg body weight. After IM dosing, mean values for PK parameters were:
clearance 0.519 L/kg/h; terminal half-life 4.64 h and volume of distribution
3.425 L/kg. Mean values for terminal half-life and clearance were 4.03 h and
0.608 L/kg/h; respectively, after SC administration. The mean area under the
plasma concentration versus time curves (AUC) were 2.455 and 2.154 µgh/ml, respectively, after IM and SC dosing and for
bioavailability means were 100% (IM) and 94% (SC). Integration of in vivo PK data with in vitro minimum inhibitory
concentration (MIC) against a pathogenic strain of P. multocida provided mean values of AUC24h/MIC
ratios of 30h and 27.5h, respectively, after IM and SC dosing of danofloxacin. After IM and SC dosing, Cmax/MIC
ratios were 3.70, and 3.62, respectively. Dosage schedules of danofloxacin for P. multocida were 5.20 mg/kg and 6.10 mg/kg per day for IM
and SC routes of administration, respectively.
Key Words: Buffalo calves, Danofloxacin,
Intramuscular, Subcutaneous, Pharmacokinetics, PK-PD integration, Dosage
determination.
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