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OJVRTM
Online Journal of Veterinary Research©
Volume 21(8):511-516, 2017.
Inflammatory cytokines in vaccinated
Cobb broilers challenged with Newcastle Disease Virus
Mina Afsar1, Saeed Nazifi1, Habiballah
Dadras1, Maryam Ansari-Lari2,
Mohammad Jafar Taebipour1
1Department of Clinical Studies, 2Food Hygiene,
School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
ABSTRACT
Afsar M, Nazifi S, Dadras H, Ansari-Lari M, Taebipour MJ.,
Inflammatory cytokines in vaccinated Cobb broilers challenged with Newcastle
Disease Virus, Onl J Vet Res., 21(8):511-516,
2017. Values for
inflammatory serum cytokines IFN-γ, TNF-α, IL-1 and IL-6 in
vaccinated broilers experimentally challenged with Newcastle disease virus
(NDV) are described. Groups of 75, 20d old Cobb broilers were vaccinated live
B1 Hitchner, killed or adjuvanted
Newcastle vaccines. At 27d, chicks were challenged with velogenic
NDV JF820294.1 propagated in 10d embryonated chicken eggs. Controls were not
challenged. Increases in cytokines were observed in all groups except controls
suggesting inflammation following challenge with NDV. Higher level of cytokines
occurred in chicks vaccinated live virus suggesting
that it may induce less inflammation than killed or adjuvanted
vaccine. NDV induced less inflammation in presence of a NDV vaccine with virus.
Key words Cytokines, Newcastle disease virus,
Vaccination, Broilers.