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OJVRTM
Online Journal of Veterinary Research ©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 28 (3): 140-145, 2024
In silico curcumin-papilloma
virus 16 E6 protein for oral and cervical cancer.
Ajay
Kumar Singh, Krishna Misra.
Centre
For Biomedical Magnetic Resonance, SGPGI campus,
Lucknow.
ABSTRACT
Singh
AK, Misra K., In silico curcumin-papilloma virus 16
E6 protein:oral and cervical
cancer, Onl J Vet Res., 28 (3): 140-145,
2024. Curcumin diferuloyl
methane and natural analogs demethoxy, bis-demethoxy and cyclo-curcumin,
present in rhizomes of turmeric may inhibit proliferation of tumor cells by
binding with active sites on HPV E6 protein, target for restoring tumor
suppressor p53 and allowing apoptosis of infected cells. Target nuclear protein
HPV E6 (PDB i.d. 2fk4) is 158 amino acids long, and
is the major protein actively participating in oral and cervical cancers.
Therefore, these herbal lead compounds can form the basis for potent, non-toxic
drugs for oral and cervical cancers.
KEY WORDS: HPV (Human Papilloma virus),
OC (oral cavity), PDB (Protein Data Bank).
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