2023-2035 All Rights Reserved. Online Journal of Veterinary Research . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the  before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR.This article may be copied once but may not be, reproduced or  re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


 OJVRTM

Online Journal of Veterinary Research  

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

Volume  28 (3): 140-145, 2024


In silico curcumin-papilloma virus 16 E6 protein for oral and cervical cancer.

Ajay Kumar Singh, Krishna Misra.

 

Centre For Biomedical Magnetic Resonance, SGPGI campus, Lucknow.

 

ABSTRACT

 

Singh AK, Misra K., In silico curcumin-papilloma virus 16 E6 protein:oral and cervical cancer, Onl J Vet Res., 28 (3): 140-145, 2024. Curcumin diferuloyl methane and natural analogs demethoxy, bis-demethoxy and cyclo-curcumin, present in rhizomes of turmeric may inhibit proliferation of tumor cells by binding with active sites on HPV E6 protein, target for restoring tumor suppressor p53 and allowing apoptosis of infected cells. Target nuclear protein HPV E6 (PDB i.d. 2fk4) is 158 amino acids long, and is the major protein actively participating in oral and cervical cancers. Therefore, these herbal lead compounds can form the basis for potent, non-toxic drugs for oral and cervical cancers.

 

KEY WORDS: HPV (Human Papilloma virus), OC (oral cavity), PDB (Protein Data Bank).


MAIN

 

 

FULL-TEXT (SUBSCRIPTION OR PURCHASE TITLE)