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Online Journal of Veterinary Research  

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X


Volume  28 (3): 140-145, 2024

In silico curcumin-papilloma virus 16 E6 protein for oral and cervical cancer.

Ajay Kumar Singh, Krishna Misra.


Centre For Biomedical Magnetic Resonance, SGPGI campus, Lucknow.




Singh AK, Misra K., In silico curcumin-papilloma virus 16 E6 protein:oral and cervical cancer, Onl J Vet Res., 28 (3): 140-145, 2024. Curcumin diferuloyl methane and natural analogs demethoxy, bis-demethoxy and cyclo-curcumin, present in rhizomes of turmeric may inhibit proliferation of tumor cells by binding with active sites on HPV E6 protein, target for restoring tumor suppressor p53 and allowing apoptosis of infected cells. Target nuclear protein HPV E6 (PDB i.d. 2fk4) is 158 amino acids long, and is the major protein actively participating in oral and cervical cancers. Therefore, these herbal lead compounds can form the basis for potent, non-toxic drugs for oral and cervical cancers.


KEY WORDS: HPV (Human Papilloma virus), OC (oral cavity), PDB (Protein Data Bank).