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Online Journal of Veterinary Research

Volume 24 (4):230-242, 2020.

Effect of papyrus protein and crab shell scaffold without osteoblasts on bone healing in dogs.


Saad Hassan Zebon1 Bahaa F Hussein3, Mohammed Jawad Eesa2


Department(s) of 1,2Surgery, 3Anatomy, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq.




Zebon SH, Hussein BF, Eesa MJ., Effect of papyrus protein and crab shell scaffold without osteoblasts on bone healing in dogs, Onl J Vet Res., 24 (4):230-242, 2020. Critical-size bone defects normally do not heal when left untreated. We describe a porous biodegradable scaffold without osteoblasts. The scaffold was then monitored for tibia repair implant in dogs. Serum alkaline phosphatase and calcium were determined at days 0, 1, 7, 10, 20, 30, 60 and 90 of implant. In dogs we found the implant induced bone formation in a 1 cm e defect in the tibia. In dogs with scaffold bone union occurred by 3 months in contrast with non-implanted controls. Compared with controls serum alkaline phosphatase in dogs with scaffold were ~33 to 41%s higher (P < 0.05) between days 20 and 90 suggesting osteoblastic and osteogenic activity associated with bone growth. We surmise that our scaffolds promoted osteoblastic activity without need for osteoblasts seeding.


Key word: Al-kharit papyrus, Crab Shell, Tissue Engineering, Bioceramic Scaffold, Dogs.