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Effect of Remdesivir and Chloroquine on hypertensive ACE drugs in COVID 19 patients.
Tayseer Shaker Mahmood
Department of Nursing, Al-Hadi University College, Baghdad, Iraq
Mahmood TS., Effect of Remdesivir and Chloroquine on hypertensive ACE drugs in COVID 19 patients, Onl J Vet Res., 25 (5): 350-353, 2021. Coronaviruses of single sense strand RNA genome are enveloped viruses infecting humans and animals responsible for severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and SARS-CoV2 COVID-19 responsible for worldwide pandemic with ~2M deaths to date. To manage hypertension, patients are given angiotensin converting enzyme receptor blockers (ACE) but there is scant information of possible interaction with COVID 19 treatments. Potential therapies for COVID 19 before severe symptoms are manifested include hydroxychloroquine, chloroquine phosphate, remdemsivir, ivermectin and lopinavir/ritonavir with or without zinc. Hypertensive COVID 19 patients using ACE receptor inhibitors are at increased risk by enhancing ACE2 blockers in epithelial cells lining the lung, where SARS-CoV-2is more likely to infect these cells via ACE2 receptors. Similarly, ACEI and ARBs drugs are shown to interact with several antiretroviral drugs leading to increase viral load. Chloroquine has an antagonistic effect with remdesivir which leads to decrease therapeutic activity of remdesivir. These results highlight possible risk of combination therapies with ACEI and ACE2.
Keyword: COVID-19, SARS, Remdesivir, Chloroquine, Antagonism, ACEI.