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OJVRTM

 

Online Journal of Veterinary Research©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

Volume 29 (2): 57-64, 2025.

Pathology induced by intradermal, intranasal and oral inoculums of Corynebacterium pseudotuberculosis in goats.

 

Adza Rina MN, Zamri-Saad M, Jesse FFA, Saharee AA, Haron AW, Shahirudin S.

 

1Research Centre for Ruminant Diseases, Department(s) of Veterinary Clinical Studies, Veterinary Pathology & Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Malaysia

 

ABSTRACT

 

Adza Rina MN, Zamri-Saad M, Jesse FFA, Saharee AA, Haron AW, Shahirudin S., Pathology induced by intradermal, intranasal and oral inoculums of Corynebacterium pseudotuberculosis in goats, Onl J Vet Res., 29 (2): 57-64, 2025.  Groups of 5 goats each were injected 1ml intradermal, intranasal and oral inoculums with 107 CFU/ml live C. pseudotuberculosis. Five control goats were not infected. Clinical signs and body temperatures were recorded and jugular blood taken for hematology and serum biochemistry. At day 30 goats were killed and prescapular, submandibular, supramammary, inguinal, mesenteric lymph nodes lungs, livers and kidneys were excised for bacterial isolation and histopathology. Goats given C. pseudotuberculosis had increased (p<0.05) temperatures for 1st week. Goats given intradermal inoculum had high (P < 0.05) leukocytes and transaminases and severe abscesses in lymph nodes. Grossly and microscopically we found pulmonary and renal congestion and liver abscesses. However, in goats given intranasal inoculum we found severe mesenteric lymph node lesions whereas in those given the oral form these lesions occurred in supra-mammary lymph nodes. Our results suggested that intradermal C. pseudotuberculosis induced severe widespread lesions in goats.

 

Key words: Pathology, intra dermal, nasal, oral, Corynebacterium pseudotuberculosis, goats.

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