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OJVRTM
Online Journal of
Veterinary Research©
Volume 24 (2):126-135, 2020.
Effects of sodium salicylate, antibiotics and
guaifenesin on histopathology and mortality
in broilers with infectious bronquitis
and influenza viruses.
Mohieddin
Hemmati, Bahman Abdi-Hachesoo,
Pouria Motamed Chaboki
Department of Clinical Sciences, School of
Veterinary Medicine, Shiraz University, Shiraz, Iran.
ABSTRACT
Hemmati M, Abdi-Hachesoo
B, Chaboki PM., Effects of sodium salicylate, antibiotics
and guaifenesin on histopathology and mortality in broilers with infectious bronquitis and influenza viruses., Onl
J Vet Res., 24 (2):126-134, 2020. Five groups of
chicks were infected with infectious bronchitis virus IRFIBV32 isolate, 1 × 104
EID50, by eye drop and avian influenza virus H9N2 subtype, 1 × 109
EID50, intranasally. Thirty-six hours after
inoculation, one group received 50 mg/kg BW sodium salicylate, another 20mg/kg
doxycycline with 30mg/kg erythromycin, and another group 12.8mg/kg the expectorant
guaifenesin for 3 days via drinking water. Lastly another group of birds were
given the 3 drugs simultaneously at the same doses mentioned above. Infected
controls were infected with both viruses but not treated, and normal controls
inoculated with sterile saline and not treated. One day before challenge and at
the end of experiment, birds were bled and sera tested for IB and AI antibodies
by ELISA and H9N2 antigens. After viral challenges clinical signs and lesions
were scored and tracheas tested for IBV by RT-PCR. Compared with infected
controls, sodium salicylate or antibiotics reduced mortality, tracheal
histopathology or symptoms. However, the expectorant guaifenesin given in
drinking water, exarcebated signs and histopathology
but reduced overall mortality. Treatment with the combined drugs decreased
mortality rate and reduced clinical sign scores most compared with other
treatments or infected controls.
Key words: Broilers, Avian influenza, Infectious bronchitis,
Sodium salicylate, Doxycycline, Erythromycin, Guaifenesin