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Online Journal of Veterinary Research

Volume 24 (4):257-262, 2020.

Effect of Colicin V on E. coli K99 induced diarrhea in infant mice.

Fatemeh Golestan1, Yahya Tahamtan2*, Elham Moazemian3


Department (s) 1Bacteriology, Azad University, Jahrom branch 2Razi Vaccine and Serum Research Institute, Shiraz,3Azad University Science Research Fars branch, Shiraz, Iran.




Golestan F, Tahamtan Y, Moazemian EM., Effect of Colicin V on E. coli K99 induced diarrhea in infant mice. Onl J Vet Res., 24 (4):257-262, 2020. Effect of E. coli colicin V on diarrhea caused by E. coli K99 in infant mice is described. Genotypes E coli from cattle were verified by PCR for colicin genes. Six groups of 8 balb-c infant mice each were gavaged 1/2ml Colicin (colicin controls), E. coli K99 (E coli controls), Colicin first and after E. coli K99 (treated before) or vice versa (treated after). Mice were monitored for mortality for 7 days and gastrointestinal tract sections were excised for bacteriology and histopathology. All colicin controls survived but only one E coli K99 (~12%) control mouse did. In those given colicin before challenge with E coli K99 we found 88% survival whereas in those given the colicin after challenge survival was only 70%. We found no pathology in mice given colicin per se or in those treated before challenge.


Keyword: Infant mice, Colicin-V, E. coli K99.