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OJVRTM
Online
Journal of Veterinary Research ©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 28
(1): 32-36, 2024
Effect of
Mormordica dioica on
cognitive impairment in mice.
Deshpande
PS, Page AB
School of Pharmacy
and Technology Management, SVKM’s, NMIMS, Shirpur,
India.
ABSTRACT
Deshpande PS, Page AB., Effect of Mormordica
dioica on neurotoxicity induced cognitive impairment
in mice, Onl J Vet Res., 28 (1): 32-36,
2024. The effect of
oral phenytoin (25mg/kg) on mice cognition was evaluated by passive avoidance
test. A significant (P<0.001), improvement
in cognitive status of mice was observed when the drug was administered with a methanolic extract of Momordica dioica. However the extract had no effect on MES. The extract of Momordica dioica
reduced the effective dose (12.5mg/kg) and subsided
phenytoin induced cognitive impairment in mice.
Key Words:
Phenytoin, M indica, neurotoxicity, cognition, mice.
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