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Online Journal of Veterinary Research © 

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X


Volume 28 (1): 32-36, 2024

Effect of Mormordica dioica on cognitive impairment in mice.


Deshpande PS, Page AB


School of Pharmacy and Technology Management, SVKM’s, NMIMS, Shirpur, India.




Deshpande PS, Page AB., Effect of Mormordica dioica on neurotoxicity induced cognitive impairment in mice, Onl J Vet Res., 28 (1): 32-36, 2024. The effect of oral phenytoin (25mg/kg) on mice cognition was evaluated by passive avoidance test. A significant (P<0.001), improvement in cognitive status of mice was observed when the drug was administered with a methanolic extract of Momordica dioica. However the extract had no effect on MES. The extract of Momordica dioica reduced the effective dose (12.5mg/kg) and subsided phenytoin induced cognitive impairment in mice.


Key Words: Phenytoin, M indica, neurotoxicity, cognition, mice.