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OJVRTM
Online Journal of Veterinary Research©
Inflammatory markers in experimental caprine
coccidiosis.
Tadayon Sa, Razavi
SMa, Nazifi Sb.
aDepartment(s) of
Pathobiology, bClinical Studies, School of Veterinary Medicine, Shiraz University, Iran
ABSTRACT
Tadayona,
S., Razavia, S.M., Nazifib, S., Inflammatory markers in experimental caprine
coccidiosis. Onl J Vet Res., 20(7):486-491,
2016. Twenty kid goats aged
2-4 months were given sulfonamide for 5 consecutive
days and maintained free of coccidia for 14 days. Ten kids were then infected orally with
5×104 sporulated oocysts E. caprina: 28500, E.
ninakohlyakimovae: 14000, and E. arloingi: 7500 in 200 ml distilled
water per animal. Another 10
uninfected kids given 200ml saline were used as controls. Blood samples were collected
from both groups before infection and at days 3, 7, 14, 21, 28 and 35
post-infection. Fecal
oocysts in infected goats appeared at 14 days in 4 goats and 17 days in 6
goats. All infected kids developed dehydration, anorexia and depression
followed by diarrhea by day 19. Peak fecal shedding occurred at 17-25 days with
a mean value of 21×104 oocysts per gram of feces. Serum adenosine deaminase activity
(ADA), total (TSA), lipid-bound (LSA) and protein-bound sialic acid (PSA) were
significantly higher by 3 to 7 days after infection compared with controls. In
particular
serum ADA activity increased by 3 days, peaked at 14
days and fell from day 35. The findings suggest the markers may be useful for
early signs of coccidia in kid goats.
Key words: Adenosine deaminase activity, Total
sialic acid, Lipid-bound sialic acid, Protein-bound sialic acid, Caprine coccidiosis.
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