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Online Journal of Veterinary Research

 Volume 21(11):751-755, 2017.

Effect of Citrus aurantifulia seed extract cream on cutaneous wound healing in male Sprague-Dawley rats


Mohammad Mahdi Zangeneh1*, Milad Alahmoradi1, Masoud Shamohammadi1, Milad Khazaei1, Amir Amiri-Paryan2, Adel Akbari1,

Reza Tahvilian3, Akram Zangeneh2, Rohallah Moradi3


Department(s) of 1Clinical and 2Basic Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran ". *Corresponding Author: Mohammad Mahdi Zangeneh, *Email: zangeneh1371@yahoo.com




Zangeneh MM, Alahmoradi M, Shamohammadi M, Khazaei M, Amiri-Paryan A, Akbari A, Tahvilian R, Zangeneh A, Moradi R., Effect of Citrus aurantifulia seed extract cream on cutaneous wound healing in male Sprague-Dawley rats, Onl J Vet Res., 21(11):751-755, 2017. Several plant products have been used in treatment of wounds over the years. Citrus aurantifulia (CA) has been used for antioxidant, anti-inflammatory, antipyretic, antibacterial and anti-fungal properties. Authors describe effect of CA seeds aqueous extract cream on cutaneous wound healing in Sprague-Dawley male rats. Full-thickness excisional wounds (22 cm) were performed on dorsum of 32 rats and treated with 1ml basal Eucerin cream, 1ml CA aquatic extract cream 10%, and 1ml tetracycline (3%) for 20 days. Animals of each group were euthanized at 20 day post-injury and wounds were assessed through gross and histopathological analyses. Size of wounds, re-epithelialization and epithelial formation in rats given CA were significantly different compared with other groups (p<0.05). Number of lymphocytes declined but fibrocytes and fibroblasts increased in CA group at 20 days (p<0.05). Results suggest that CA seed aqueous extract cream applied topically may promote healing.


Keywords: Citrus aurantifulia, seeds, aqueous extract; cream; wound healing.