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OJVRTM
Online Journal of Veterinary Research©
Volume 22
(3):210-215, 2018.
Effect of L-Carnitine on semen
of adult NMRI mice given prolonged Cimetidine.
Mina Kiani
MSca, Paria Parto PhDb
aDepartment of Biology, Faculty
of Sciences, Razi University, Kermanshah, Iran, and bBiology Department, Prince George`s Community College,
MD, USA
ABSTRACT:
Kiani M, Parto P., Effect of
L-Carnitine on semen of adult NMRI mice injected prolonged Cimetidine, Onl J Vet Res., 22 (3):210-215, 2018. Cimetidine is given for stomach ulcers, but its prolonged
use can affect
the male reproductive system. We report effects of L-carnitine on semen from adult mice treated daily
for 15 days with 100mg/kg cimetidine. Groups of 5 NMRI mice each
were injected intraperitoneally (IP) with 100 mg/kg cimetidine,
100 mg/kg L- carnitine, or 100 mg/kg cimetidine
with 100mg L- carnitine in phosphate buffered saline (PBS) daily for 15 days. Controls
were injected
1ml/L PBS IP. Cimetidine caused a decrease (P≤0.05) in motility, viability
and normal morphology, but did not affect sperm count. Compared with mice given only cimetidine, L-
carnitine with cimetidine increased (P≤0.05) sperm count, motility,
viability and normal
morphology. Our findings suggest that L- carnitine prevented toxic effects
of cimetidine in sperm of adult NMRI mice.
Key
Words: Cimetidine, L-Carnitine,
semen, mice.
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