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OJVRTM
Online Journal of Veterinary Research©
(Including Medical
and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 28(7): 387-394, 2024.
Plasma and
tissue cholinesterase in broilers gavaged dichlorvos and carbaryl
Fouad KM , Banan Al-Baggou
Department of Physiology, Biochemistry and
Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq
Abstract
Fouad KM, Al-Baggou B., Plasma and tissue cholinesterase in broilers
gavaged dichlorvos and carbaryl,, Onl J Vet Res., 28(7):
387-394, 2024. We determined plasma, brain and liver cholinesterase in twenty one
45 days old broilers. ChE was measured in 0.2 ml
plasma or tissue homogenate, 3ml distilled water, 3ml pH 8.1 phosphate-barbital
buffer and 0.12 ml 7.5% acetylthiocholine iodide
substrate incubated 30min at 37 ˚C.
Reference ChE in plasma were 0.47, brain 0.25
and liver 0.21 ΔpH/30 min. We found highest cholinesterase in plasma
and lowest in liver. Gavage of 7mg/kg dichlorvos or
100mg/kg carbaryl induced salivation, frequent defecation,
tremors and difficult gait. Compared with control cholinesterase, Dichlorvos (P< 0.05) inhibited 62% plasma, 29% brain and
33% liver levels whereas Carbaryl reduced it by 28%
in plasma and 65% in brain. Carbaryl did not affect ChE in liver (P>0.05).
KEY-WORDS: Cholinesterase, broilers, dichlorvos, carbaryl.
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