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OJVRTM
Online Journal of Veterinary Research©
Volume 7:26-32, 2003. Redacted
2018.
Pharmacokinetics of cefepime
in lactating goats: Tissue cage fluid and milk concentrations.
Rule R1,4, Lacchini R2, Arauz S3, Mordujovich
P4
1Comisión de Investigaciones Científicas de la
Provincia de Buenos Aires, 2Cátedra de Introducción
a la Zootecnia. F.C.A. y F.,
U.N.L.P. 3Servicio
Central de Laboratorio. F.C.V., U.N.L.P,4Cátedra
de Farmacología, F.C.M., U.N.L.P. Argentina
SUMMARY
Rule R, Lacchini
R, Arauz S, Mordujovich P,
Pharmacokinetics of cefepime
in lactating goats:Tissue cage fluid and milk
concentrations. Onl J Vet Res., 7:26-32, 2003. Serum, tissue
fluid (TCF) and milk cefepime concentrations after IV
and IM administration were determined in lactating goats with and without
tissue damage produced by the implantation of tissue cages. In Trial 1,
20 mg/kg was given IV and IM separated by a weekly interval. A Trial 2 was
commenced 8 weeks after implant. TCF total protein/total serum protein
ratios were 83.8 and 67.5% (p< 0.05) at the 1st and 8th week after implant.
After IV in Trial 1 and 2, AUC (serum) was 98.5 ± 5.3 and 68.5 ± 11.1 µg/ml/h
(p< 0.05); CL (serum), 208 ± 13 and 370 ± 40 ml/h/kg (p< 0.05); AUC
(TCF), 89.6 ± 11.6 and 177.1 ± 15 µg/ml/h Cmax (TCF),
17.6 ± 2.4 and 38.8 ± 6.1 µg/ml (p< 0.05), ) and penetration (milk), 8.7 ±
1.7 and 9.6 ± 1.6 %, respectively. After IM, AUC (serum) was 57.7 ± 4.0 and
95.7 ± 12.3 µg/ml/h (p< 0.05); t1/2a (serum), 0.1 ± 0.02 and 0.5 ± 0.1 h; tmax (serum), 0.4 ± 0.1 and 1.0 ± 0.1 h (p< 0.05) and
penetration (milk), 8.5 ± 1.7 and 9.0 ± 2.7%; respectively. The results suggest
that cefepime given IM or IV to lactating goats, produces
high concentration-time values in serum and tissue fluid, but low penetration
levels in milk.
KEY WORDS: Pharmacokinetics, cefepime, tissue cage fluid, lactating goats.