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OJVRTM
Online Journal of
Veterinary Research©
Volume 4 (5): 62-68, 2001. Redacted
2018.
Pharmacokinetics of cefepime®in normal and mastitic
goats.
Rule Ra,b,
Rubio Mc, Mordujovich Pb,
García Roman Ad .
a Comisión de Investigaciones Científicas de la
Provincia de Buenos Aires,bCátedra
de Farmacología, Facultad
de Medicina, U.N.L.P., Argentina. cININFA (CONICET). d Departamento de Farmacología y Toxicología, Universidad de Cordoba. España,
Address for correspondence: Roberto Rule. Calle 63 Nro. 216. La Plata (1900).
Argentina. Email : rrule@atlas.med.unlp.edu.ar
ABSTRACT
Pharmacokinetics of cefepime® in normal and mastitic goats. Rule R,
Rubio M, Mordujovich P, García
Roman A. Onl J Vet Res., 5:62-68, 2001. Ten goats were given 100 mg cefepime® intra-mammarily 3 times
every 12 hours. Serum and milk non-compartmental pharmacokinetic values in
normal and mastitic glands were determined. Mean cefepime® half-lives in serum and milk were 1.2 and 2.1
hours whereas in mastitis were 2.2 and 3.0 hours, respectively. Mean residence
times (MRT) were 2.0 and 3.7, and 4.9 and 6.5 hours, respectively and mean
areas under the curve were 1.4 and 5542, and 5.2 and 3908
µg.ml-1.ml, respectively. MRT and penetration (%) of cefepime®
in milk and serum was significantly higher in mastitis but the antibiotic was
detected in both groups 3-4 days after the last dose. The results suggest that cefepime® had improved penetration in mastitis, provided
high concentrations in milk for 12 hours after 1 dose, and persisted up to 4
days after a third dose.
KEY WORDS: Cefepime®,
pharmacokinetics, mastitis, goats.