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OJVRTM
Online Journal of Veterinary Research©
Volume 21(7):358-366, 2017.
Effect of L- carnitine on
spermatogenesis and sperm parameters in NMRI mice treated with spironolactone
Mina Kiani
MSca, Paria Partob
PhD, Ahmad Gharzia PhD.
aDepartment
of Biology, Faculty of Sciences, Razi University,
Kermanshah, Iran, bDepartment of
Biology, Prince George’s Community College, Largo, MD, USA
ABSTRACT
Kiani M, Parto P, Gharzia
A., Effect of L- carnitine on spermatogenesis and sperm parameters in NMRI mice
treated with spironolactone, Onl J Vet Res.,
21(7):358-366, 2017. Spironolactone has anti-androgenic properties,
yet is widely used to control hypertension and congestive heart failure.
Authors describe effect of the antioxidant L-carnitine on spermatogenesis,
sperm and seminiferous tubules in groups of 5 NMRI mice each given spironolactone
or not. Mice were injected intraperitoneally (IP) phosphate buffered saline as
drug solvent (controls), or spironolactone 50 mg⁄kg
IP, L- carnitine 100 mg⁄kg
IP or spironolactone 50 mg⁄kg with L- carnitine
100 mg⁄kg IP daily for 15 days. Body and testis
weights, spermatocytes, spermatid, sperm counts and diameter of seminiferous
tubules values in mice given spironolactone decreased compared with controls (P
≤0.05). In mice given L-carnitine with spironolactone, testis weight, spermatogonia, spermatids, sperm and seminiferous tubule
diameter, increased compared with those given spironolactone (
P ≤0.05).
Keywords:
Testis, L- Carnitine, Spironolactone, Spermatogenesis, sperm parameters.
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