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Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

Volume 27 (9):508-515, 2023.

Diagnosis of cutaneous melanomas and squamous cell carcinomas in horse and cattle by staining antigens.


Farhang Sasani, Javad Javanbakht, Mehdi Aghamohammad Hassan, Farajollaheh Adibhashemi, Soheila Hemmati.


Faculty of Veterinary Medicine, Tehran University, Iran.




Sasani F, Javanbakht J, Hassan MA, Adibhashemi F, Hemmati S., Diagnosis of cutaneous melanomas and squamous cell carcinomas in horse and cattle by staining antigens, Onl J Vet Res., 27(9): 508-515, 2023. Authors describe histopathology of cutaneous melanoma and squamous cell carcinoma in horses and cattle by hematoxylin eosin, fontana-masson silver, immune S-100 and HMB45 antigen stains. In 6 of 9 melanomas, S-100 protein and HMB45 stain were positive whereas by Fontana-Masson silver and melanin bleaching, all tumors were positive. However 3 of 4 squamous cell carcinomas were negative to all tests. Diagnosis of suspicious melanoma tumor cases should be confirmed or reconfirmed by special staining methods or immunohistochemistry.


Key words: Melanoma, Squamous Cell Carcinoma, HMB45 antigen, S-100 protein, Immunohistochemical.