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Online Journal of Veterinary Research©

 

Volume 10 (1) : 68 -75, 2006. Redacted 2018.

Predicted pharmacokinetic model for carbamazepine in the rabbit.

 

Rukhadze M1,2*, Bezarashvili G1, Alexishvili M1, Fischer N3, Sebiskveradze M2, Okujava N2

 

1Department of Chemistry and 2Laboratory of Neurobiology, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia, 3HELIOS Hospital  Gotha/Ohrdruf, Helios street 1, 99867 Gotha, Germany

 

ABSTRACT

 

Rukhadze M, Bezarashvili G, Alexishvili M, Fischer N, Sebiskveradze M, Okujava N Predicted pharmacokinetic model for carbamazepine in the rabbit. Onl J Vet Res., 10 (1): 68-75, 2006. Absorption and elimination kinetics of carbamazepine (oral) in rabbits were determined by a successive substitution procedure combined with correlation and regression analysis. Increased dosages altered Ka and Kel considerably suggesting a step-wise absorption of carbamazepine. Kinetic equations were derived, which quantitatively describe the changes in the level of carbamazepine against time based on exponential step-wise functions. The absorption of carbamazepine at high doses is probably realized stepwise, by successive joining up of different reservoirs. The biochemical transformation of absorbed drug may occur by its interaction with enzymes. Therefore, the kinetic characteristics (rate constant, kinetic order) of biotransformation process have different values in a series of experiments. Increased doses of carbamazepine increases the number of reservoirs and decreases the elimination order from one to zero.

 

Key words: Experimental and predicted pharmacokinetic curves, carbamazepine, conceptual model, reservoirs, exponential function, step-wise function.

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