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OJVRTM

Online Journal of Veterinary Research

Established 1994

ISSN 1328-925X

 

Volume 22 (9):847-850, 2018.


Effect of oral cadmium chloride on glutathione and malondialdehyde

in kidney, liver and brain tissues of young female albino rabbits.

 

Khalid Ahmed Hadi , Wasan Sarhan Oubied, Dakheel Hussein Hadree.

 

Department of Physiology, Biochemistry and Pharmacology, Faculty of Veterinary Medicine, University of Tikrit, Iraq

 

ABSTRACT

 

Hadi KA, Oubied WS, Hadree DH., Effect of oral cadmium chloride on glutathione and malondialdehyde in kidney, liver and brain tissues of young female albino rabbits, Onl J Vet Res., 22 (9):847-850, 2018. Cadmium can induce severe changes in tissues due to lipid peroxidation and free radical generation. Six 2-3 month old female albino rabbits were supplied 25mg/L cadmium in drinking water over 45 days. At 45 days rabbits were sacrificed for glutathione, glutathione peroxidase and malondialdehyde levels in kidney, liver and brain tissues. Controls were given water without cadmium. Compared with controls (P < 0.05), glutathione was 46-66% and glutathione peroxidase 45-75% lower, but malondialdehyde 15-38% higher in those tissues. Glutathione and glutathione peroxide decreased most in liver (66-75%), but malondialdehyde increased most in brain tissue (38%)

 

Key words : cadmium chloride, female rabbit raw data provided.