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Online Journal of Veterinary Research


Volume 19(5): 317-324, 2015.

Histopathological and immunohistochemical findings from bovine viral diarrhea virus infection in cattle.


Khodakaram-Tafti A1, Mohammadi A1, Farjanikish GH2


1Department(s) of Pathobiology, School of Veterinary Medicine, Shiraz University, 2School of Veterinary Medicine, Lorestan University, Khorram Abad, Iran




Khodakaram-Tafti A, Mohammadi A, Farjanikish GH., Histopathological and immuno-histochemical findings from bovine viral diarrhea virus infection in cattle, Onl J Vet Res., 19(5): 317-321, 2015. Tissues from ileum, cecum, colon, liver and ear skin of 18 and 19 month old Holstein cows with a history of anorexia, fever, diarrhea and death were fixed in 10% buffered formalin for histopathological and immune-histochemical evaluation. In the intestines, necrosis of epithelial cells, mononuclear inflammatory cell infiltration of mucosa and submucosa, cryptitis with herniation of crypts in submucosa, and depletion of lymphoid follicles in the ileum occurred. Immuno-reactivity to bovine viral diarrhea virus (BVDV) antigen was observed in epithelial cells of villi and Lieberkuhn glands, crypt epithelial cells in dilated and herniated crypts, hepatocytes and kupffer cells, basal and spinosum cells, hair follicle epithelial cells and endothelial cells of vasculature of the dermis. The findings suggested acute persistent BVDV infection.

Key words: bovine viral diarrhea virus, histopathology, immunohistochemistry, cattle.