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OJVR®
Online Journal of Veterinary Research©
Volume 1:35-41, 2002, Redacted 2018.
Pulmonary Hypertensive Syndrome of broilers:Effect of cold (12Co)
exposure on cardio-hepatic
mitochondrial malonilaldehyde and
superoxide dismutase activity
Sijun Yang, Dingzhong Guo, Baoan
Yao
College
of Animal Science and Veterinary Medicine, Huazhong
Agricultural University, Wuhan 430070 China
ABSTRACT
Yang S, Guo D, Yao B., Pulmonary Hypertensive Syndrome of broilers:Effect of cold (12Co)
exposure on cardio-hepatic mitochondrial malonilaldehyde
and superoxide dismutase activity, Onl J Vet Res.,
1:35-41, 2002. Recent
findings show that Pulmonary Hypertension Syndrome (PHS) in broilers is
associated with increased malonyl-aldehyde (MDA) and
decreased superoxide-dismutase (SOD) levels in tissues suggesting a causal
relationship between oxidative stress and pathology. In this study, values from
2 groups of two hundred 21 day old broilers reared at 24 and 12Co,
respectively, were compared until 49 days of age. In broilers exposed to 12Co,
right (RV) total ventricle (TV) weight ratio increased 37%, cardio-hepatic SOD
activity decreased 25-36% and cardio-hepatic MDA increased 38-40%. The results
suggest that cold exposure induced cardio-hepatic mitochondrial membrane
oxidative stress supporting a role for free radicals in the pathogenesis of PHS
in broilers.
KEYWORDS: Ascites syndrome, Mitochondria, Malonyl-aldehyde, free radicals, antioxidants
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